Immunoregulation of infectious diseases

RESEARCH GROUP’S MISSION

Our laboratory and its projects focus in the comprehension of the modulation of immune and biochemistry response and them inter-relation with development of pathologies during Trypanosoma cruzi, Toxoplasma gondii and Plasmodium sp infections. To elucidate the relevant compound, from both pathogens and host, to induction and repression of immune response against microorganism, we apply experiments both in vitro and in vivo, using pharmacology and molecular biology tools. Among our mainly goal are the studies to determine the participation of eicosanoids (as lipoxins) and them receptors in the regulation of immune response and the development of pathologies during T. cruzi and others pathogens infection. Moreover, we are developing studies to identify and characterize the biochemistry and immunologic molecules of T. cruzi and T. gondii that possible modulate directly the host immune response during the infections. In summary, our goal is to investigate the potential therapeutic manipulation of the generation and activity of pro- and anti-inflammatory mediators during infectious disease in experimental animals, contributing to development of new strategies to prevent against development of diseases.

TEAM

Coordinator

  Dr. Fabiana Simão Machado

Post-doctoral  

  Melisa Gualdrón Lopez 

PHD Students       

  Bruno Cabral de Lima Oliveira

  Fatima Maria Caldeira Brant Costa

  Lisia Maria Esper

  Pollyana Maria de Oliveira Pimentel 

 Master Students

  Cynthia Honorato Val

  Ronan Ricardo Sabino Araújo 

Undergraduate Students

  Andréia Barroso Gonçalves

  Diego Rodney Rodrigues de Assis  

  Isabela de Avellar Costa  

  Julia Teixeira de Castro